Clinical results

Clinical studies have been conducted by various medical teams worldwide, providing consistent data on safety and efficacy


UCP has been used worldwide to treat more than 10 000 patients

Average IOP reduction at 12 months

Based on 6-sector protocol

Success rate of 70-80% at 12-18 months

* success is defined as IOP reduction > 20% and final IOP > 5 mmHg without supplemental hypotensive medications

Efficacy – Multiple treatments

« Clinical studies have shown the overall procedure efficacy to improve after multiple UCP treatments » 1
« Repeated UCP has to be considered in patients with target IOP not reached, and in patients with early or delayed IOP increase» 2

Source 1 : Safety and efficacy of multiple cyclocoagulation of ciliary bodies by high-intensity focused ultrasound in patients with glaucoma – Dra De Gregorio & All – Graefe’s Archives for clinical and experimental ophthalmology – October 2017

Source 2 : Aptel F et al. Efficacy and safety of repeated Ultrasound Cycloplasty procedures in patients with early or delayed failure after a first procedure. J Glaucoma, 2020 Jan; 29(1):24-30


UCP generally shows a good safety profile with no major complication

Click here to see scientific references

Clinical References

Ultrasound Cyclo Plasty for Treatment of Surgery-Naïve Open-Angle Glaucoma Patients: A Prospective, Multicenter, 2-Year Follow-Up Trial
Journal of Clinical Medecine 2021, J. Clin. Med. 2021, 10(21), 4982

Michele Figus,Chiara Posarelli, Marco Nardi, Ingeborg Stalmans, Evelien Vandewalle, Shlomo Melamed, Alon Skaat, Ari Leshno, David Cordeiro Sousa and Luis Abegão Pinto

High-intensity focused ultrasound in the treatment of glaucoma: a narrative review
Expert Review of Ophthalmology, Volume 10,2021 - Issue 3 - Pages 161-174
Michele Figus, Francesco Sartini, Giuseppe Covello & Chiara Posarelli

Efficacy and Safety of Ultrasound Cycloplasty for Refractory Glaucoma: A 3-Year Study
Journal of Glaucoma 2021, May 2021 - Volume 30 - Issue 5, p428-435

Rouland, Jean-François MD, FEBO*; Aptel, Florent MD, PhD†

A 2-year prospective multicenter study of ultrasound cyclo plasty for glaucoma
Scientific Reports volume 11, Article number: 12647 (2021)

Giannaccare G, Pellegrini M, Bernabei F, Urbini L, Bergamini. F, Desideri LF, Bagnis A, Biagini F, Cassottana P, Del Noce C, Carnevali A, Scorcia V, Traverso CE, Vagge A. 

Efficacy and safety of repeated ultrasound cycloplasty procedures in patient with early or delayed failure after a first procedure

Journal of Glaucoma: January 2020 - Volume 29 - Issue 1 - p 24-30

Aptel, Florent MD, PhD*; Tadjine, Mehdi MD*; Rouland, Jean-François MD†

The Influence of Ultrasound Ciliary Plasty on Corneal Parameters
Journal of Glaucoma: October 2020 - Volume 29 - Issue 10 - p 899-904

Bolek, Bartłomiej MD; Wylęgała, Adam MD, PhD; Wylęgała, Edward MD, PhD

High intensity focused ultrasound for glaucoma: 1-year results from a prospective pragmatic study
Eye - Volume 35, pages 484–489 (2021)

Raquel E. Marques, Nuno P. Ferreira, David C. Sousa, André Diogo Barata, Paula Sens, Carlos Marques-Neves & Luis Abegão Pinto

Safety and efficacy of ultrasound ciliary plasty as a primary intervention in glaucoma patients
International Journal of Ophthalmology, Volume 12, No. 4, Apr.18, 2019

Magda A. Torky, Yousif A Al Zafri , Sherein M. Hagras , Abeer M. Khattab , Rania M. Bassiouny , Tharwat H. Mokbel

Application of high intensity focused ultrasound for treatment of open-angle glaucoma In Indian patients
Indian Journal of Ophthalmology - Vol 66, Issue 4, April 2018

Nilanjana Deb‑Joardar, Kasu Prasad Reddy

Safety and efficacy of multiple cyclocoagulation of ciliary bodies by high-intensity focused ultrasound in patients with glaucoma
Graefe's Archive for Clinical and Experimental Ophthalmology - Volume 255, pages2429–2435 (2017)

Alessandra De Gregorio & Emilio Pedrotti & Giulia Stevan & Margherita Montali  & Simonetta Morselli