Clinical results

Clinical studies have been conducted by various medical teams worldwide, providing consistent data on safety and efficacy

Efficacy

UCP has been used worldwide to treat more than 10 000 patients

Average IOP reduction at 12 months

Based on 6-sector protocol

Success rate of 70-80% at 12-18 months
 

* success is defined as IOP reduction > 20% and final IOP > 5 mmHg without supplemental hypotensive medications

Efficacy – Multiple treatments

Complete success: IOP < 21mmHg
UCP treatment was repeated at 4 months if needed
 
Population: 40 patients, 35% of POAG, 42% with previous filtering surgery, 65% non POAG, 7.5% angle closure, 20% exfoliative, 30% neovascular, 7.5% other

Source : Safety and efficacy of multiple cyclocoagulation of ciliary bodies by high-intensity focused ultrasound in patients with glaucoma – Dra De Gregorio & All – Graefe’s Archives for clinical and experimental ophthalmology – October 2017

Safety

UCP generally shows a good safety profile with no major complication

Click here to see scientific references

Clinical Studies

Efficacy and safety of repeated ultrasound cycloplasty procedures in patient with early or delayed failure after a first procedure

Aptel F., Tadjine M., Rouland JF - Journal of Glaucoma - January 2020

  • Analysis of 31 patients retreated in a cohort of 141 patients
  • Retreatment improves the overall cumulative success rate
  • IOP significantly reduced after 2nd treatment (12 months follow-up)

Glaucoma treatment with high intensity focused ultrasound – results at 3 years for a population of 104 patients
Rouland JF, Aptel F, SFO 2019, poster # 245

  • 104 patients (naïve of surgery), 36 months follow-up, prospective multicentric study
  • Success rate of 55% at 36 months
  • Mean IOP reduction of 33% with IOP baseline of 27.6 +/- 8.9 mmHg

Ultrasound cyclo plasty in surgery naïve open angle glaucoma patients. Interim month -18 results of a prospective multicenter clinical trial
Pinto L. et al., WGC 2019, poster # 1312

  • 66 patients (naïve of surgery), 18 months follow-up, prospective multicentric study
  • Success rate of 70% at 12 months
  • Mean IOP reduction of 34% with IOP baseline of 24.3 +/- 2.9 mmHg

Safety and efficacy of ultrasound ciliary plasty as a primary intervention in glaucoma patients
Torky M. et al., International Journal of ophthalmology 2019

  • 62 patients (naïve of surgery), 12 months follow-up, prospective multicentric study
  • Success rate of 77% at 12 months
  • Mean IOP reduction of 42% with IOP baseline of 35.2 +/- 8.3 mmHg

Application of high intensity focused ultrasound for treatment of open-angle glaucoma In Indian patients
Deb N. et al., Indian journal of ophthalmology 2019

  • 73 patients (naïve of surgery), 12 months follow-up, prospective monocentric study
  • Success rate of 78% at 12 months
  • Mean IOP reduction of 30% with IOP baseline of 23.5 +/-3 mmHg

High intensity focused ultrasound for glaucoma – one year results from a prospective pragmatic study
Sousa D. et al, WGC 2019, poster # P-FS-116

  • 51 patients (refractory and naïve of surgery), 12 months follow-up, prospective multicentric study
  • Success rate of 80% at 12 months
  • Mean IOP reduction of 33% with IOP baseline of 26.7 +/- 7.7 mmHg

Ultrasound cycloplasty in patients with glaucoma: 1 year results from a multicenter prospective study
Giannaccare G., Traverso C. et al, Ophthalmic Research Journal 2018

  • 49 patients (refractory), 12 months follow-up, prospective multicentric study
  • Success rate of 75% at 12 months
  • Mean IOP reduction of 30% with IOP baseline of 27.7 +/- 9.2 mmHg

Ultrasound cyclo plasty for treatment of surgery naïve open angle glaucoma patients. Interim results at 1 year of a prospective multicenter clinical trial
Figus M. et al., EGS 2018, Poster # P4-072

  • 66 patients (naïve of surgery), 12 months follow-up, prospective multicenter study
  • Success rate of 65%
  • Mean IOP reduction of 31% with IOP baseline of 24.3 +/-2.9mmHg

Safety and efficacy of multiple cyclocoagulation of ciliary bodies by high-intensity focused ultrasound in patients with glaucoma
De Gregorio A. et al., Graefes Arch Clin Exp Ophthalmol 2017

  • 40 patients (refractory and naïve of surgery), 12 months follow-up, prospective monocentric study
  • Success rate of 85% at 12 months after last treatment on a complex population (35% POAG), with systematic retreatment at 4 months for unsuccessful patients
  • Mean IOP reduction of 35% with IOP baseline of 32.5 +/-9.9mmHg

High-intensity focused ultrasound cyclo-coagulation
Sousa D. et al., AAO 2017, Poster # 368

  • 46 patients (refractory and naïve of surgery), 12 months follow-up, prospective multicenter study
  • Success rate of 79%
  • Mean IOP reduction of 34% with IOP baseline of 27.2 +/-7.9mmHg